Resurgence of SARS-CoV-2 Infection in a Highly Vaccinated Health System Workforce

doi:10.1056/NEJMc2112981

. 2021 Sep 30;385(14):1330-1332.

doi: 10.1056/NEJMc2112981. Epub 2021 Sep 1.

Resurgence of SARS-CoV-2 Infection in a Highly Vaccinated Health System Workforce

Jocelyn Keehner¹, Lucy E Horton¹, Nancy J Binkin², Louise C Laurent¹; SEARCH Alliance; David Pride³, Christopher A Longhurst³, Shira R Abeles³, Francesca J Torriani³

Collaborators, Affiliations

Collaborators

SEARCH Alliance:
Stefan Aigner, Kristian G Andersen, Catelyn Anderson, Nathan A Baer, Tom Barber, Pedro Belda-Ferre, Maryann Betty, Amanda Birmingham, Anelizze Castro-Martinez, Marison Chacón, Willi Cheung, Evelyn S Crescini, Peter De Hoff, Emily R Eisner, Kathleen Fisch, Lizbeth Franco Vargas, Karthik Gangavarapu, Abbas Hakim, Benjamin Henson, Charlotte Hobbs, Greg Humphrey, Kristen Jepsen, Bhavika K Kapadia, Rob Knight, Alma L Lastrella, Louise C Laurent, Elijah S Lawrence, Michal Machnicki, Clarisse A Marotz, Nathaniel L Matteson, Daniel J Maunder, Niema Moshiri, Toan T Ngo, Alhakam Nouri, Tyler R Ostrander, Ashley Plascencia, Christopher A Ruiz, Rodolfo A Salido, Shashank Sathe, Phoebe Seaver, Elizabeth W Smoot, Rebecca Tsai, Min Yi Wu, Bing Xia, Gene W Yeo, Mark Zeller

Affiliations

¹ UC San Diego Health, San Diego, CA.
² UC San Diego, La Jolla, CA.
³ UC San Diego Health, San Diego, CA ftorriani@health.ucsd.edu.

PMID: 34469645
PMCID: PMC8451183
DOI: 10.1056/NEJMc2112981

Resurgence of SARS-CoV-2 Infection in a Highly Vaccinated Health System Workforce

Jocelyn Keehner et al. N Engl J Med. 2021.

. 2021 Sep 30;385(14):1330-1332.

doi: 10.1056/NEJMc2112981. Epub 2021 Sep 1.

Authors

Jocelyn Keehner¹, Lucy E Horton¹, Nancy J Binkin², Louise C Laurent¹; SEARCH Alliance; David Pride³, Christopher A Longhurst³, Shira R Abeles³, Francesca J Torriani³

Collaborators

SEARCH Alliance:
Stefan Aigner, Kristian G Andersen, Catelyn Anderson, Nathan A Baer, Tom Barber, Pedro Belda-Ferre, Maryann Betty, Amanda Birmingham, Anelizze Castro-Martinez, Marison Chacón, Willi Cheung, Evelyn S Crescini, Peter De Hoff, Emily R Eisner, Kathleen Fisch, Lizbeth Franco Vargas, Karthik Gangavarapu, Abbas Hakim, Benjamin Henson, Charlotte Hobbs, Greg Humphrey, Kristen Jepsen, Bhavika K Kapadia, Rob Knight, Alma L Lastrella, Louise C Laurent, Elijah S Lawrence, Michal Machnicki, Clarisse A Marotz, Nathaniel L Matteson, Daniel J Maunder, Niema Moshiri, Toan T Ngo, Alhakam Nouri, Tyler R Ostrander, Ashley Plascencia, Christopher A Ruiz, Rodolfo A Salido, Shashank Sathe, Phoebe Seaver, Elizabeth W Smoot, Rebecca Tsai, Min Yi Wu, Bing Xia, Gene W Yeo, Mark Zeller

Affiliations

¹ UC San Diego Health, San Diego, CA.
² UC San Diego, La Jolla, CA.
³ UC San Diego Health, San Diego, CA ftorriani@health.ucsd.edu.

PMID: 34469645
PMCID: PMC8451183
DOI: 10.1056/NEJMc2112981

No abstract available

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Figures

**Figure 1. SARS-CoV-2 Variants among Symptomatic Health Workers.**
Shown is the distribution of the B.1.1.7 (alpha), delta, and other SARS-CoV-2 variants according to vaccination status and month of diagnosis among health workers at University of California San Diego Health, March through July 2021. The number of workers indicates those who were symptomatic and had available variant data, and the number of positive tests indicates those that included data on variants.

See this image and copyright information in PMC

Comment in

SARS-CoV-2 Infection in Vaccinated Health Care Workers.
Lilleri D, Marena C, Baldanti F. Lilleri D, et al. N Engl J Med. 2022 Jan 13;386(2):199-200. doi: 10.1056/NEJMc2117119. Epub 2021 Dec 15. N Engl J Med. 2022. PMID: 34910861 No abstract available.

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SARS-CoV-2 Symptoms during the Omicron Surge Differ between Boosted and Vaccinated Non-Boosted Persons.
Montecalvo MA, Visintainer P, Drugge E, Kowalski K, Raffa R, McKenna D, Moronta C, Wormser GP. Montecalvo MA, et al. Vaccines (Basel). 2024 Mar 19;12(3):327. doi: 10.3390/vaccines12030327. Vaccines (Basel). 2024. PMID: 38543961 Free PMC article.
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Patel DR, Minns AM, Sim DG, Field CJ, Kerr AE, Heinly TA, Luley EH, Rossi RM, Bator CM, Moustafa IM, Norton EB, Hafenstein SL, Lindner SE, Sutton TC. Patel DR, et al. Microbiol Spectr. 2024 Mar 5;12(3):e0499822. doi: 10.1128/spectrum.04998-22. Epub 2024 Feb 9. Microbiol Spectr. 2024. PMID: 38334387 Free PMC article.
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Walmsley S, Nabipoor M, Lovblom LE, Ravindran R, Colwill K, McGeer A, Dayam RM, Manase D, Gingras AC, On Behalf Of The STOPCoV Team. Walmsley S, et al. Vaccines (Basel). 2023 Dec 28;12(1):36. doi: 10.3390/vaccines12010036. Vaccines (Basel). 2023. PMID: 38250849 Free PMC article.
Integrated Genomic and Social Network Analyses of SARS-CoV-2 Transmission in the Healthcare Setting.
Keehner J, Abeles SR, Longhurst CA, Horton LE, Myers FE, Riggs-Rodriguez L, Ahmad M, Baxter S, Boussina A, Cantrell K, Cardenas P, De Hoff P, El-Kareh R, Holland J, Ikeda D, Kurashige K, Laurent LC; SEARCH Alliance; Lucas A, Pride D, Sathe S, Tran AR, Vasylyeva TI, Yeo G, Knight R, Wertheim JO, Torriani FJ. Keehner J, et al. Clin Infect Dis. 2024 May 15;78(5):1204-1213. doi: 10.1093/cid/ciad738. Clin Infect Dis. 2024. PMID: 38227643

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References

1. Keehner J, Abeles SR, Torriani FJ. More on SARS-CoV-2 infection after vaccination in health care workers. reply. N Engl J Med 2021;385(2):e8. - PubMed
1. Baden LR, El Sahly HM, Essink B, et al. Efficacy and safety of the mRNA-1273 SARS-CoV-2 vaccine. N Engl J Med 2021;384:403-416. - PMC - PubMed
1. Thomas SJ, Moreira ED Jr, Kitchin N, et al. Six month safety and efficacy of the BNT162b2 mRNA COVID-19 vaccine. July 28, 2021. (https://www.medrxiv.org/content/10.1101/2021.07.28.21261159v1). preprint. - DOI
1. Lopez Bernal J, Andrews N, Gower C, et al. Effectiveness of Covid-19 vaccines against the B.1.617.2 (Delta) variant. N Engl J Med 2021;385:585-594. - PMC - PubMed
1. Israel A, Merzon E, Schäffer AA, et al. Elapsed time since BNT162b2 vaccine and risk of SARS-CoV-2 infection in a large cohort. August 5, 2021. (https://www.medrxiv.org/content/10.1101/2021.08.03.21261496v1). preprint. - DOI - PMC - PubMed

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[1] Keehner J, Abeles SR, Torriani FJ. More on SARS-CoV-2 infection after vaccination in health care workers. reply. N Engl J Med 2021;385(2):e8. - PubMed

[2] Keehner J, Abeles SR, Torriani FJ. More on SARS-CoV-2 infection after vaccination in health care workers. reply. N Engl J Med 2021;385(2):e8. - PubMed

[3] Baden LR, El Sahly HM, Essink B, et al. Efficacy and safety of the mRNA-1273 SARS-CoV-2 vaccine. N Engl J Med 2021;384:403-416. - PMC - PubMed

[4] Baden LR, El Sahly HM, Essink B, et al. Efficacy and safety of the mRNA-1273 SARS-CoV-2 vaccine. N Engl J Med 2021;384:403-416. - PMC - PubMed

[5] Thomas SJ, Moreira ED Jr, Kitchin N, et al. Six month safety and efficacy of the BNT162b2 mRNA COVID-19 vaccine. July 28, 2021. (https://www.medrxiv.org/content/10.1101/2021.07.28.21261159v1). preprint. - DOI

[6] Thomas SJ, Moreira ED Jr, Kitchin N, et al. Six month safety and efficacy of the BNT162b2 mRNA COVID-19 vaccine. July 28, 2021. (https://www.medrxiv.org/content/10.1101/2021.07.28.21261159v1). preprint. - DOI

[7] Lopez Bernal J, Andrews N, Gower C, et al. Effectiveness of Covid-19 vaccines against the B.1.617.2 (Delta) variant. N Engl J Med 2021;385:585-594. - PMC - PubMed

[8] Lopez Bernal J, Andrews N, Gower C, et al. Effectiveness of Covid-19 vaccines against the B.1.617.2 (Delta) variant. N Engl J Med 2021;385:585-594. - PMC - PubMed

[9] Israel A, Merzon E, Schäffer AA, et al. Elapsed time since BNT162b2 vaccine and risk of SARS-CoV-2 infection in a large cohort. August 5, 2021. (https://www.medrxiv.org/content/10.1101/2021.08.03.21261496v1). preprint. - DOI - PMC - PubMed

[10] Israel A, Merzon E, Schäffer AA, et al. Elapsed time since BNT162b2 vaccine and risk of SARS-CoV-2 infection in a large cohort. August 5, 2021. (https://www.medrxiv.org/content/10.1101/2021.08.03.21261496v1). preprint. - DOI - PMC - PubMed

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Resurgence of SARS-CoV-2 Infection in a Highly Vaccinated Health System Workforce

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Resurgence of SARS-CoV-2 Infection in a Highly Vaccinated Health System Workforce

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