Helicobacter pylori GroEL Seropositivity Is Associated with an Increased Risk of Opisthorchis viverrini-Associated Hepatobiliary Abnormalities and Cholangiocarcinoma

Isabelle Jala; Muhammad Luthfi Almanfaluthi; Thewarach Laha; Sakawrat Kanthawong; Sirikachorn Tangkawattana; Prasert Saichua; Sutas Suttiprapa; Banchob Sripa

doi:10.3347/kjp.2021.59.4.363

Helicobacter pylori GroEL Seropositivity Is Associated with an Increased Risk of Opisthorchis viverrini-Associated Hepatobiliary Abnormalities and Cholangiocarcinoma

Korean J Parasitol. 2021 Aug;59(4):363-368. doi: 10.3347/kjp.2021.59.4.363. Epub 2021 Aug 18.

Authors

Isabelle Jala^{1

2}, Muhammad Luthfi Almanfaluthi^{1

2}, Thewarach Laha³, Sakawrat Kanthawong⁴, Sirikachorn Tangkawattana^{2

5}, Prasert Saichua^{1

2}, Sutas Suttiprapa^{1

2}, Banchob Sripa^{2

6}

Affiliations

¹ Tropical Medicine Graduate Program (International Program), Academic Affairs, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
² WHO Collaborating Centre for Research and Control of Opisthorchiasis (Southeast Asian Liver Fluke Disease), Tropical Disease Research Centre, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
³ Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
⁴ Department of Microbiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
⁵ Department of Pathobiology, Faculty of Veterinary Medicine, Khon Kaen University, Khon Kaen, Thailand.
⁶ Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.

Abstract

Despite the synergistic effect of Opisthorchis viverrini and Helicobacter pylori co-infection on pathogenesis of severe hepatobiliary abnormalities (HBA) including advanced periductal fibrosis and replace with cholangiocarcinoma (CCA) have been established, the immune response to H. pylori in O. viverrini infected population has never been explored. Hence, this study aimed to investigate the antibody responses to 2 immunogenic H. pylori proteins in O. viverrini-infected patients with HBA and CCA. The risk analysis by multinomial logistic regression revealed that GroEL seropositivity was associated with higher risks of hepatobiliary abnormalities and CCA with adjusted odds ratios (95% confidence intervals) of 2.11 (95% CI=1.20-3.71, P=0.008) and 2.13 (95% CI=1.21-3.75, P=0.009), respectively. These findings indicate that GroEL seropositivity might be a biomarker for early detection of O. viverrini associated HBA and CCA.

Keywords: Helicobacter pylori; Opisthorchis viverrini; cholangiocarcinoma; hepatobiliary abnormality; risk factor.

MeSH terms

Animals
Bile Duct Neoplasms*
Bile Ducts, Intrahepatic
Cholangiocarcinoma*
Helicobacter pylori*
Humans
Opisthorchiasis* / complications
Opisthorchis*

Abstract

MeSH terms

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