Atypical Histological Features as Risk Factors for Recurrence in Newly Diagnosed WHO Grade I Meningioma

Neurol Med Chir (Tokyo). 2021 Nov 15;61(11):647-651. doi: 10.2176/nmc.oa.2021-0153. Epub 2021 Sep 1.

Abstract

The significance of atypical histological features (AHF) as risk factors for recurrence in benign meningioma is not well understood. This study examined risk factors of World Health Organization (WHO) Grade I meningioma (GIM) recurrence, focusing on AHF. We investigated 150 consecutive newly diagnosed GIM patients who had more than one year of follow-up after resection in our hospital between January 2007 and March 2018. The following factors were reviewed retrospectively: age, sex, tumor location, extent of resection, MIB-1 index, mitotic figures, number and distribution of AHF, and recurrence. The patients were grouped according to the presence or absence of recurrence and comparatively examined. Recurrence was observed in 10 cases (6.7%). Univariate analysis showed that patients with recurrence had a significantly higher MIB-1 index (2.0 vs. 4.3; p = 0.006) and a significantly higher proportion of male patients (21.4% vs. 70.0%; p = 0.002) and patients with sheet-like growth (6.42% vs. 30.0%; p = 0.04). In multivariate analysis, skull base location (odds ratio [OR] 31.424; 95% confidence interval [CI] 1.74-569), gross total resection (OR 0.130; 95% CI 0.0189-0.897), and MIB-1 index (OR 1.939; 95% CI 1.19-3.15) were significantly associated with recurrence. Our study revealed that skull base location, subtotal resection, and high MIB-1 index were independent risk factors for recurrence. Only the presence of sheet-like growth had a significantly higher incidence in patients with recurrence in univariate analysis of AHF. Multivariate analysis found no significant association. Sheet-like growth may be involved in malignancy and recurrence of benign meningioma.

Keywords: atypical histological features; benign meningioma; recurrence; risk factor.

MeSH terms

  • Child
  • Humans
  • Male
  • Meningeal Neoplasms* / epidemiology
  • Meningeal Neoplasms* / surgery
  • Meningioma* / epidemiology
  • Meningioma* / surgery
  • Neoplasm Recurrence, Local / epidemiology
  • Retrospective Studies
  • Risk Factors
  • World Health Organization