Effects of administered thromboxanes on the intact, normal rat kidney

Ren Physiol. 1987;10(2):110-21. doi: 10.1159/000173120.

Abstract

The effects of administered thromboxanes on the intact, normal rat kidney were studied. Euvolemic male rats received intraarterial infusions of thromboxane B2 (TXB2) and the stable thromboxane A2 analog (U46619) and the effects on renal function were investigated, using glomerular micropuncture and whole-kidney clearance techniques. Both TXB2 and U46619 were renal vasoconstrictors and lowered GFR by reducing renal plasma flow rate; U46619 was much more potent that TXB2. Neither agent caused any marked change in the glomerular capillary ultrafiltration coefficient (Kf). Thus in the rat, the thromboxanes reduce filtration rate by increasing renal vascular resistance and without exerting a marked influence on Kf.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Kidney / drug effects
  • Kidney / physiology*
  • Kidney Glomerulus / drug effects
  • Kidney Glomerulus / physiology
  • Kidney Tubules / drug effects
  • Kidney Tubules / physiology
  • Male
  • Rats
  • Rats, Inbred Strains
  • Thromboxane A2 / analogs & derivatives*
  • Thromboxane A2 / pharmacokinetics
  • Thromboxane B2 / pharmacokinetics
  • Thromboxanes / administration & dosage
  • Thromboxanes / pharmacology*
  • Urodynamics / drug effects

Substances

  • Thromboxanes
  • Thromboxane B2
  • Thromboxane A2