Effect of an ionic antineoplastic agent Cytoreg on blood chemistry in a Wistar rat model

Med Gas Res. 2022 Jan-Mar;12(1):18-23. doi: 10.4103/2045-9912.324592.


Cytoreg is an ionic therapeutic agent comprising a mixture of hydrochloric, sulfuric, phosphoric, hydrofluoric, oxalic, and citric acids. In diluted form, it has demonstrated efficacy against human cancers in vitro and in vivo. Although Cytoreg is well tolerated in mice, rats, rabbits, and dogs by oral and intravenous administration, its mechanism of action is not documented. The acidic nature of Cytoreg could potentially disrupt the pH and levels of ions and dissolved gases in the blood. Here, we report the effects of the intravenous administration of Cytoreg on the arterial pH, oxygen and carbon dioxide pressures, and bicarbonate, sodium, potassium, and chloride concentrations. Our results demonstrate that Cytoreg does not disturb the normal blood pH, ion levels, or carbon dioxide content, but increases oxygen levels in rats. These data are consistent with the excellent tolerability of intravenous Cytoreg observed in rabbits, and dogs. The study was approved by the Bioethics Committee of the University of the Andes, Venezuela (CEBIOULA) (approval No. 125) on November 3, 2019.

Keywords: Cytorex; Warburg effect; acid-base homeostasis; arterial blood chemistry; electrolyte balance; ion therapy; oxygen pressure; tissue oxygenation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acid-Base Equilibrium*
  • Animals
  • Antineoplastic Agents* / pharmacology
  • Bicarbonates / pharmacology
  • Dogs
  • Hydrogen-Ion Concentration
  • Mice
  • Rabbits
  • Rats
  • Rats, Wistar


  • Antineoplastic Agents
  • Bicarbonates