A prospective, randomized study of 5-fluorouracil and filtration surgery

Trans Am Ophthalmol Soc. 1987;85:238-53.


Our study shows that use of a small dose of subconjunctival 5-FU provides significantly lower postoperative intraocular pressure than does no antimetabolite treatment. Morphology of the postoperative blebs suggests that increased filtration results in lower intraocular pressure in the 5-FU group. Corneal epithelial defects were as common with a low dose as with higher doses previously described.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Child
  • Female
  • Fluorouracil / therapeutic use*
  • Glaucoma / pathology
  • Glaucoma / surgery*
  • Humans
  • Intraocular Pressure / drug effects
  • Male
  • Middle Aged
  • Postoperative Care
  • Postoperative Complications / prevention & control*
  • Prospective Studies
  • Random Allocation


  • Fluorouracil