Predicting neonatal outcomes in infants with giant omphalocele using prenatal magnetic resonance imaging calculated observed-to-expected fetal lung volumes

Prenat Diagn. 2021 Oct;41(11):1439-1448. doi: 10.1002/pd.6040. Epub 2021 Sep 9.


Objective: To examine the association between prenatal magnetic resonance imaging (MRI) based observed/expected total lung volume (O/E TLV) and outcome in neonates with giant omphalocele (GO).

Methods: Between 06/2004 and 12/2019, 67 cases with isolated GO underwent prenatal and postnatal care at our institution. MRI-based O/E TLVs were calculated based on normative data from Meyers and from Rypens and correlated with postnatal survival and morbidities. O/E TLV scores were grouped based on severity into <25% (severe), between 25% and 50% (moderate), and >50% (mild) for risk stratification.

Results: O/E TLV was calculated for all patients according to Meyers nomograms and for 49 patients according to Rypens nomograms. Survival for GO neonates with severe, moderate, and mild pulmonary hypoplasia based on Meyers O/E TLV categories was 60%, 92%, and 96%, respectively (p = 0.04). There was a significant inverse association between Meyers O/E TLV and risk of neonatal morbidities (p < 0.05). A similar trend was observed with Rypens O/E TLV, but associations were less often significant likely related to the smaller sample size.

Conclusion: Neonatal outcomes are related to fetal lung size in isolated GO. Assessment of Meyers O/E TLV allows identification of GO fetuses at greatest risk for complications secondary to pulmonary hypoplasia.

MeSH terms

  • Female
  • Fetus / physiology
  • Gestational Age
  • Hernia, Umbilical / diagnosis*
  • Hernia, Umbilical / epidemiology
  • Humans
  • Infant, Newborn
  • Lung / growth & development*
  • Lung Volume Measurements / instrumentation
  • Lung Volume Measurements / methods
  • Magnetic Resonance Imaging / methods
  • Magnetic Resonance Imaging / standards*
  • Magnetic Resonance Imaging / statistics & numerical data
  • Nomograms
  • Noninvasive Prenatal Testing / methods
  • Noninvasive Prenatal Testing / standards*
  • Noninvasive Prenatal Testing / statistics & numerical data
  • Pregnancy
  • Pregnancy Outcome / epidemiology
  • Retrospective Studies