Bacteria and fungi: The counteracting modulators of immune responses to radiation therapy in cancer

Cancer Cell. 2021 Sep 13;39(9):1173-1175. doi: 10.1016/j.ccell.2021.08.004. Epub 2021 Sep 2.


In this issue of Cancer Cell, Shiao et al. reveal the counteracting role of bacteria and fungi in antitumoral immune responses to radiation therapy (RT). While bacterial depletion impairs the response, fungal depletion improves efficacy of RT. An interplay between innate and adaptive immunity is implicated and orchestrated by Dectin-1.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Bacteria
  • Fungi
  • Humans
  • Immunity, Innate
  • Lectins, C-Type*
  • Neoplasms* / radiotherapy


  • Lectins, C-Type