The endothelium-bone axis in development, homeostasis and bone and joint disease

Nat Rev Rheumatol. 2021 Oct;17(10):608-620. doi: 10.1038/s41584-021-00682-3. Epub 2021 Sep 3.

Abstract

Blood vessels form a versatile transport network that is best known for its critical roles in processes such as tissue oxygenation, metabolism and immune surveillance. The vasculature also provides local, often organ-specific, molecular signals that control the behaviour of other cell types in their vicinity during development, homeostasis and regeneration, and also in disease processes. In the skeletal system, the local vasculature is actively involved in both bone formation and resorption. In addition, blood vessels participate in inflammatory processes and contribute to the pathogenesis of diseases that affect the joints, such as rheumatoid arthritis and osteoarthritis. This Review summarizes the current understanding of the architecture, angiogenic growth and functional properties of the bone vasculature. The effects of ageing and pathological conditions, including arthritis and osteoporosis, are also discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aging / physiology
  • Animals
  • Arthritis / physiopathology
  • Bone Development* / physiology
  • Bone Diseases / drug therapy
  • Bone Diseases / physiopathology*
  • Bone Regeneration / drug effects
  • Bone Regeneration / physiology
  • Bone and Bones* / blood supply
  • Bone and Bones* / physiology
  • Bone and Bones* / physiopathology
  • Chondrocytes / physiology
  • Endothelium, Vascular* / physiology
  • Endothelium, Vascular* / physiopathology
  • Fractures, Bone / physiopathology
  • Homeostasis* / physiology
  • Humans
  • Joint Diseases / drug therapy
  • Joint Diseases / physiopathology*
  • Macrophages / physiology
  • Mice
  • Neovascularization, Pathologic / drug therapy
  • Neovascularization, Pathologic / physiopathology
  • Neovascularization, Physiologic / physiology
  • Osteoblasts / physiology
  • Osteogenesis / physiology
  • Osteoporosis / drug therapy
  • Osteoporosis / physiopathology
  • Receptor Cross-Talk / physiology
  • Synoviocytes / physiology