Outcomes of activated prothrombin complex concentrate for direct Xa inhibitor bleeding

Maureen A Smythe; John M Koerber; Janet L Hoffman; Sean Mertz; Karissa Fritsch; Fatme Chehab; Nour Baalbaki; Anant Krishnan

doi:10.1016/j.thromres.2021.08.011

Outcomes of activated prothrombin complex concentrate for direct Xa inhibitor bleeding

Thromb Res. 2021 Oct:206:142-144. doi: 10.1016/j.thromres.2021.08.011. Epub 2021 Aug 17.

Authors

Maureen A Smythe¹, John M Koerber², Janet L Hoffman³, Sean Mertz⁴, Karissa Fritsch⁵, Fatme Chehab⁶, Nour Baalbaki⁷, Anant Krishnan⁸

Affiliations

¹ Department of Pharmacy Services, Beaumont Hospital, 3601 West 13 Mile Road, MI 48073, USA; Department of Pharmacy Practice, Suite 2190, Wayne State University, 259 Mack Avenue, Detroit, MI 48202, USA. Electronic address: Maureen.smythe@beaumont.org.
² Department of Pharmacy Services, Beaumont Hospital, 3601 West 13 Mile Road, MI 48073, USA; Department of Pharmacy Practice, Suite 2190, Wayne State University, 259 Mack Avenue, Detroit, MI 48202, USA. Electronic address: john.koerber@beaumont.org.
³ Department of Pharmacy Services, Beaumont Hospital, 3601 West 13 Mile Road, MI 48073, USA; Department of Pharmacy Practice, Suite 2190, Wayne State University, 259 Mack Avenue, Detroit, MI 48202, USA. Electronic address: janet.hoffman@beaumont.org.
⁴ Department of Pharmacy Services, Beaumont Hospital, 3601 West 13 Mile Road, MI 48073, USA. Electronic address: sean.mertz@ketteringhealth.org.
⁵ Department of Pharmacy Services, Beaumont Hospital, 3601 West 13 Mile Road, MI 48073, USA. Electronic address: karissa-fritsch@uiowa.edu.
⁶ Department of Pharmacy Services, Beaumont Hospital, 3601 West 13 Mile Road, MI 48073, USA; Department of Pharmacy Practice, Suite 2190, Wayne State University, 259 Mack Avenue, Detroit, MI 48202, USA. Electronic address: fatme.chehab@beaumont.org.
⁷ Department of Pharmacy Services, Beaumont Hospital, 3601 West 13 Mile Road, MI 48073, USA; Department of Pharmacy Practice, Suite 2190, Wayne State University, 259 Mack Avenue, Detroit, MI 48202, USA. Electronic address: nour.baalbaki@ascension.org.
⁸ Department of Diagnostic Radiology, Beaumont Hospital, 3601 West 13 Mile Road, Royal Oak, MI 48073, USA. Electronic address: Anant.krishnan@beaumont.org.

PMID: 34481221
DOI: 10.1016/j.thromres.2021.08.011

No abstract available

Keywords: Anticoagulants; Apixaban; Bleeding; FEIBA; Reversal; Rivaroxaban.

MeSH terms

Administration, Oral
Anticoagulants / adverse effects
Blood Coagulation Factors* / therapeutic use
Factor VIIa / therapeutic use
Factor Xa Inhibitors / therapeutic use
Hemorrhage* / chemically induced
Hemorrhage* / drug therapy
Humans
Pyridones / therapeutic use
Rivaroxaban / therapeutic use

Substances

Anticoagulants
Blood Coagulation Factors
Factor Xa Inhibitors
Pyridones
prothrombin complex concentrates
Rivaroxaban
Factor VIIa