Biotransformation of 3-methylphthalate by Micrococcus sp. strain 12B

J Gen Microbiol. 1987 Sep;133(9):2473-6. doi: 10.1099/00221287-133-9-2473.


When Micrococcus strain 12B grown on o-phthalate was incubated with 3-methylphthalate, three compounds accumulated. These were shown to be 2-pyrone-3-methyl-4,6-dicarboxylic acid, 3,4-dihydroxy-6-methylphthalic acid, and 5-hydroxy-3-methyphthalic acid, all previously undescribed. A pathway for the formation of these compounds is proposed.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Biotransformation
  • Chromatography, Gel
  • Micrococcus / metabolism*
  • Phthalic Acids / pharmacokinetics*


  • Phthalic Acids
  • 3-methylphthalate