[The efficiency of probiotics in the prevention of recurrent lower urinary tract infections and bacterial vaginosis]

Urologiia. 2021 Sep:(4):30-34.
[Article in Russian]


Introduction: The literature data indicate that bacterial vaginosis (BV) increases the risk of development of lower urinary tract infections (LUTI). Thus, it is reasonable to assume that the use of probiotics, in particular Lactoginal, can be effective in preventing relapses of LUTI.

Aim: To study the efficiency of probiotics, particularly Lactoginal, for the prevention of recurrent LUTI and BV.

Materials and methods: A total of 120 women with chronic recurrent bacterial cystitis in the acute stage and concomitant bacterial vaginosis were randomized into two groups of 60 patients. In group 1, standard antibacterial therapy was used according to guidelines of professional societies. In group 2, vaginal probiotic Lactoginal was prescribed after standard treatment.

Results: The results obtained in this study correspond to the literature data. The additional use of probiotics in the complex therapy of chronic lower urinary tract inflammation contributed to the normalization of the lactobacilli concentration in 93% of cases, in contrast to standard antibacterial therapy, after which the normal flora was preserved only in 40% of cases. In addition, a reduction in the number of relapses of BV was seen. Moreover, it was found that in the group of patients treated with Lactoginal, there was 18.3% less recurrence of cystitis within 6 months than in the control group (p<0.05).

Conclusion: The use of probiotics, in particular, Lactoginal vaginal capsules, in women with BV after antibacterial therapy contributes to a faster recovery and longer preservation of the normal vaginal flora, which allows to the prolongate the relapse-free period of both chronic bacterial cystitis and BV.

Keywords: bacterial vaginosis; lactobacilli; lower urinary tract infections.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Female
  • Humans
  • Lactobacillus
  • Probiotics* / therapeutic use
  • Urinary Tract Infections* / prevention & control
  • Vagina
  • Vaginosis, Bacterial* / drug therapy