Vaccination in acute immune-mediated/inflammatory disorders of the central nervous system

Sophia Bakhtadze; Ming Lim; Dana Craiu; Cristina Cazacu

doi:10.1016/j.ejpn.2021.07.011

Vaccination in acute immune-mediated/inflammatory disorders of the central nervous system

Eur J Paediatr Neurol. 2021 Sep:34:118-122. doi: 10.1016/j.ejpn.2021.07.011. Epub 2021 Aug 31.

Authors

Sophia Bakhtadze¹, Ming Lim², Dana Craiu³, Cristina Cazacu⁴

Affiliations

¹ Department of Paediatric Neurology, Tbilisi State Medical University, 33 Vazha Pshavela ave, 0160, Tbilisi, Georgia. Electronic address: s.bakhtadze@tsmu.edu.
² Children's Neurosciences, Evelina London Children's Hospital at Guy's and St Thomas' NHS Foundation Trust, Westminister Bridge Road, SE1 7EH, London, UK; Department Women and Children's Health, School of Life Course Sciences (SoLCS), King's College, Strand, WC2R 2LS, London, UK. Electronic address: ming.lim@gstt.nhs.uk.
³ Department of Neurosciences, Pediatric Neurology Discipline II, Carol Davila University of Medicine and Pharmacy, Faculty of Medicine, Strada Dionisie Lupu No. 37, 020021, Bucharest/S2, Romania; Pediatric Neurology Clinic, Center of Expertise for Rare Disorders in Pediatric Neurology, EpiCARE Member, Sos. Berceni 10, Bucharest/S4, Romania. Electronic address: dcraiu@yahoo.com.
⁴ Pediatric Neurology Clinic, Center of Expertise for Rare Disorders in Pediatric Neurology, EpiCARE Member, Sos. Berceni 10, Bucharest/S4, Romania. Electronic address: cristina_calusaru@yahoo.com.

PMID: 34487956
DOI: 10.1016/j.ejpn.2021.07.011

Abstract

This review article covers the vaccination related issues in autoimmune disorders of central nervous system (CNS) including narcolepsy, anti-NMDAR encephalitis, Rasmussen encephalitis and febrile infection related epilepsy syndrome (FIRES). Beyond these conditions the immune mediated epilepsies related with autoimmune CNS disorders are discussed and indications and contraindications of vaccinations in these cases are also considered.

Keywords: Anti-NMDAR encephalitis; Autoimmune encephalitis; FIRES; Immune-mediated epilepsies; Narcolepsy; Rasmussen encephalitis; Vaccination.

Publication types

Review

MeSH terms

Anti-N-Methyl-D-Aspartate Receptor Encephalitis*
Central Nervous System
Epilepsy*
Humans
Inflammation
Vaccination