Cordycepin Attenuates Palmitic Acid-Induced Inflammation and Apoptosis of Vascular Endothelial Cells through Mediating PI3K/Akt/eNOS Signaling Pathway
- PMID: 34488549
- DOI: 10.1142/S0192415X21500804
Cordycepin Attenuates Palmitic Acid-Induced Inflammation and Apoptosis of Vascular Endothelial Cells through Mediating PI3K/Akt/eNOS Signaling Pathway
Abstract
A well-known medicinal mushroom in the field of traditional Chinese medicine, Cordyceps sinensis, is a rare natural-occurring entomopathogenic fungus, and it typically grows at high altitudes on the plateau of the Himalayan. Previous studies indicated that cordycepin, the main bioactive chemical of Cordyceps sinensis, has very potent anticancer, anti-oxidant and anti-inflammatory activities. However, its protective effects against atherosclerotic changes in vascular endothelial cells have not been fully elucidated. In this study, we showed that pretreatment with cordycepin significantly attenuated palmitic acid (PA)-induced cytotoxicity, reactive oxygen species (ROS) generation, and inflammatory responses. We found that PA decreased phosphorylation of Akt, eNOS, and bioavailability of nitric oxide (NO), which in turn activated NF-[Formula: see text]B and the downstream inflammatory responses. All these detrimental events were markedly blocked by pretreatment with cordycepin. Moreover, cordycepin ameliorated destabilization of mitochondrial permeability, cytosolic calcium rises, and apoptotic features caused by PA. In addition, all these anti-inflammatory and anti-apoptosis effects of cordycepin were found to be inhibited by the PI3K and eNOS inhibitor, suggesting that its anti-atherosclerotic effects may partially be mediated by the PI3K/Akt/eNOS signaling pathway.
Keywords: Atherosclerosis; Cordycepin; Cordyceps Sinensis; Oxidative Stress; Palmitic Acid.
Similar articles
-
Ellagic acid protects endothelial cells from oxidized low-density lipoprotein-induced apoptosis by modulating the PI3K/Akt/eNOS pathway.Toxicol Appl Pharmacol. 2010 Oct 15;248(2):134-43. doi: 10.1016/j.taap.2010.07.025. Epub 2010 Aug 4. Toxicol Appl Pharmacol. 2010. PMID: 20691200
-
Cordycepin induces apoptosis in human bladder cancer T24 cells through ROS-dependent inhibition of the PI3K/Akt signaling pathway.Biosci Trends. 2019;13(4):324-333. doi: 10.5582/bst.2019.01214. Biosci Trends. 2019. PMID: 31527329
-
Cordycepin inhibits lipopolysaccharide-induced inflammation by the suppression of NF-kappaB through Akt and p38 inhibition in RAW 264.7 macrophage cells.Eur J Pharmacol. 2006 Sep 18;545(2-3):192-9. doi: 10.1016/j.ejphar.2006.06.047. Epub 2006 Jun 28. Eur J Pharmacol. 2006. PMID: 16899239
-
Cordycepin for Health and Wellbeing: A Potent Bioactive Metabolite of an Entomopathogenic Cordyceps Medicinal Fungus and Its Nutraceutical and Therapeutic Potential.Molecules. 2020 Jun 12;25(12):2735. doi: 10.3390/molecules25122735. Molecules. 2020. PMID: 32545666 Free PMC article. Review.
-
Mechanisms of Medicinal Plant Activity on Nitric Oxide (NO) Bioavailability as Prospective Treatments for Atherosclerosis.Curr Pharm Des. 2020;26(22):2591-2601. doi: 10.2174/1381612826666200318152049. Curr Pharm Des. 2020. PMID: 32188375 Review.
Cited by
-
Enhancing Vasculogenesis in Dental Pulp Development: DPSCs-ECs Communication via FN1-ITGA5 Signaling.Stem Cell Rev Rep. 2024 May;20(4):1060-1077. doi: 10.1007/s12015-024-10695-6. Epub 2024 Feb 28. Stem Cell Rev Rep. 2024. PMID: 38418738 Free PMC article.
-
6-Gingerol Ameliorates Hepatic Steatosis, Inflammation and Oxidative Stress in High-Fat Diet-Fed Mice through Activating LKB1/AMPK Signaling.Int J Mol Sci. 2023 Mar 27;24(7):6285. doi: 10.3390/ijms24076285. Int J Mol Sci. 2023. PMID: 37047258 Free PMC article.
-
Effects of β-Nicotinamide Mononucleotide, Berberine, and Cordycepin on Lipid Droplet Content and Developmental Ability of Vitrified Bovine Oocytes.Antioxidants (Basel). 2023 Apr 24;12(5):991. doi: 10.3390/antiox12050991. Antioxidants (Basel). 2023. PMID: 37237857 Free PMC article.
-
Unveiling the protective role of ESM1 in endothelial cell proliferation and lipid reprogramming.Sci Rep. 2025 May 4;15(1):15572. doi: 10.1038/s41598-025-00581-7. Sci Rep. 2025. PMID: 40320451 Free PMC article.
-
The Potential of Bioactive Fish Collagen Oligopeptides against Hydrogen Peroxide-Induced NIH/3T3 and HUVEC Damage: The Involvement of the Mitochondria.Nutrients. 2024 Mar 29;16(7):1004. doi: 10.3390/nu16071004. Nutrients. 2024. PMID: 38613037 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
