Characteristic Features of Protein Interaction with Single- and Double-Stranded RNA

Biochemistry (Mosc). 2021 Aug;86(8):1025-1040. doi: 10.1134/S0006297921080125.


The review discusses differences between the specific protein interactions with single- and double-stranded RNA molecules using the data on the structure of RNA-protein complexes. Proteins interacting with the single-stranded RNAs form contacts with RNA bases, which ensures recognition of specific nucleotide sequences. Formation of such contacts with the double-stranded RNAs is hindered, so that the proteins recognize unique conformations of the RNA spatial structure and interact mainly with the RNA sugar-phosphate backbone.

Keywords: RNA–protein interaction; RNP domain; double-stranded RNA; ribosomal proteins; single-stranded RNA.

Publication types

  • Review

MeSH terms

  • Amino Acid Motifs
  • Base Sequence
  • Humans
  • Models, Molecular
  • Nucleic Acid Conformation
  • Protein Binding
  • Protein Domains
  • Protein Folding
  • Protein Structure, Secondary
  • RNA / chemistry*
  • RNA, Double-Stranded / chemistry*
  • Zinc Fingers


  • RNA, Double-Stranded
  • RNA