Dyspnea, Elevated Jugular Venous Pulse, and Lower Extremity Edema in the Setting of Interstitial Lung Disease in a Patient Who Has Undergone Liver and Kidney Transplantation

Chest. 2021 Sep;160(3):e295-e298. doi: 10.1016/j.chest.2021.03.051.

Abstract

A 64-year-old man with a past medical history of alcoholic cirrhosis with resultant hepatorenal syndrome requiring kidney and liver transplantation 10 years previously sought treatment at the ED with progressive lower-extremity edema and dyspnea. After noting worsening shortness of breath and cough as an outpatient, he had been referred to a pulmonary clinic and was undergoing a workup for interstitial lung disease (ILD). He had been started on prednisone 40 mg/d after a lung biopsy 4 months before admission. He was also receiving chronic immunosuppression with tacrolimus and mycophenolate mofetil. He had noted worsening of edema since starting prednisone.

Publication types

  • Case Reports

MeSH terms

  • Amino Acyl-tRNA Synthetases / immunology*
  • Autoantibodies / blood*
  • Diagnosis, Differential
  • Dyspnea / diagnosis
  • Dyspnea / etiology
  • Echocardiography / methods
  • Edema
  • Heart Failure* / diagnosis
  • Heart Failure* / etiology
  • Humans
  • Immunosuppressive Agents / administration & dosage*
  • Jugular Veins / physiopathology
  • Kidney Transplantation / methods
  • Liver Transplantation / methods
  • Lung Diseases, Interstitial* / immunology
  • Lung Diseases, Interstitial* / pathology
  • Lung Diseases, Interstitial* / physiopathology
  • Male
  • Middle Aged
  • Myositis* / diagnosis
  • Myositis* / immunology
  • Myositis* / physiopathology
  • Myositis* / therapy
  • Pulmonary Arterial Hypertension* / diagnosis
  • Pulmonary Arterial Hypertension* / etiology
  • Pulmonary Arterial Hypertension* / physiopathology
  • Tomography, X-Ray Computed / methods
  • Venous Pressure

Substances

  • Autoantibodies
  • Immunosuppressive Agents
  • Amino Acyl-tRNA Synthetases

Supplementary concepts

  • Antisynthetase syndrome