Minocycline Activity against Unusual Clinically Significant Gram-Negative Pathogens

Antimicrob Agents Chemother. 2021 Oct 18;65(11):e0126421. doi: 10.1128/AAC.01264-21. Epub 2021 Sep 7.

Abstract

The minocycline susceptibility of 3,856 isolates including Burkholderia, Achromobacter, Alcaligenes, Aeromonas, and Stenotrophomonas maltophilia from the SENTRY surveillance (2014 to 2019) were analyzed. The susceptibilities of these species (%S) were Achromobacter spp. (n = 411; 92.6%), Burkholderia cepacia species complex (n = 199; 85.9%), Aeromonas spp. (n = 127; 99.2%), Chryseobacterium spp. (n = 59; 94.9%), Alcaligenes faecalis (n = 42; 88.1%), and S. maltophilia (n = 2,287; 99.5%). These data suggest that minocycline is a useful treatment option for infections caused by unusual Gram-negative pathogens.

Keywords: Achromobacter; Aeromonas; minocycline; surveillance.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Burkholderia cepacia complex*
  • Gram-Negative Bacterial Infections* / drug therapy
  • Humans
  • Microbial Sensitivity Tests
  • Minocycline / pharmacology
  • Stenotrophomonas maltophilia*

Substances

  • Anti-Bacterial Agents
  • Minocycline

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