Heritable epigenetic changes at single genes: challenges and opportunities in Caenorhabditis elegans

Mary Chey; Antony M Jose

doi:10.1016/j.tig.2021.08.011

Heritable epigenetic changes at single genes: challenges and opportunities in Caenorhabditis elegans

Trends Genet. 2022 Feb;38(2):116-119. doi: 10.1016/j.tig.2021.08.011. Epub 2021 Sep 4.

Authors

Mary Chey¹, Antony M Jose²

Affiliations

¹ Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA.
² Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA. Electronic address: amjose@umd.edu.

Abstract

Organisms rely on stereotyped patterns of gene expression for similar form and function in every generation. The analysis of epigenetic changes in the expression of different genes across generations can provide the rationale for measured actions in one generation that consider impact on future generations.

Keywords: RNAi; regulatory networks; transgenerational epigenetic inheritance (TEI).

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Animals
Caenorhabditis elegans Proteins* / genetics
Caenorhabditis elegans* / genetics
Epigenesis, Genetic
Inheritance Patterns

Substances

Caenorhabditis elegans Proteins

Grants and funding

R01 GM124356/GM/NIGMS NIH HHS/United States