Spontaneous Abortion Following COVID-19 Vaccination During Pregnancy

doi:10.1001/jama.2021.15494

Multicenter Study

. 2021 Oct 26;326(16):1629-1631.

doi: 10.1001/jama.2021.15494.

Spontaneous Abortion Following COVID-19 Vaccination During Pregnancy

Elyse O Kharbanda¹, Jacob Haapala¹, Malini DeSilva¹, Gabriela Vazquez-Benitez¹, Kimberly K Vesco², Allison L Naleway², Heather S Lipkind³

Affiliations

¹ HealthPartners Institute, Minneapolis, Minnesota.
² Center for Health Research, Kaiser Permanente Northwest, Portland, Oregon.
³ Obstetrics and Gynecology, Yale University, New Haven, Connecticut.

PMID: 34495304
PMCID: PMC8427483
DOI: 10.1001/jama.2021.15494

Multicenter Study

Spontaneous Abortion Following COVID-19 Vaccination During Pregnancy

Elyse O Kharbanda et al. JAMA. 2021.

. 2021 Oct 26;326(16):1629-1631.

doi: 10.1001/jama.2021.15494.

Authors

Elyse O Kharbanda¹, Jacob Haapala¹, Malini DeSilva¹, Gabriela Vazquez-Benitez¹, Kimberly K Vesco², Allison L Naleway², Heather S Lipkind³

Affiliations

¹ HealthPartners Institute, Minneapolis, Minnesota.
² Center for Health Research, Kaiser Permanente Northwest, Portland, Oregon.
³ Obstetrics and Gynecology, Yale University, New Haven, Connecticut.

PMID: 34495304
PMCID: PMC8427483
DOI: 10.1001/jama.2021.15494

Erratum in

Transposed Column Heads in Table.
[No authors listed] [No authors listed] JAMA. 2021 Oct 5;326(13):1331. doi: 10.1001/jama.2021.16235. JAMA. 2021. PMID: 34505868 Free PMC article. No abstract available.

Abstract

This study presents findings from case-control surveillance of COVID-19 vaccination during pregnancy and spontaneous abortion.

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Conflict of interest statement

Conflict of Interest Disclosures: Dr Lipkind reported serving on the Pfizer independent external data monitoring committee for the COVID-19 vaccine. Dr Naleway reported receiving research funding from Pfizer for an unrelated study. Dr Vesco reported receiving research funding from Pfizer for an unrelated study. No other disclosures were reported.

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References

1. Ko JY, DeSisto CL, Simeone RM, et al. . Adverse pregnancy outcomes, maternal complications, and severe illness among US delivery hospitalizations with and without a coronavirus disease 2019 (COVID-19) diagnosis. Clin Infect Dis. 2021;73(suppl 1):S24-S31. doi:10.1093/cid/ciab344 - DOI - PMC - PubMed
1. Shimabukuro TT, Kim SY, Myers TR, et al. ; CDC v-safe COVID-19 Pregnancy Registry Team . Preliminary findings of mRNA COVID-19 vaccine safety in pregnant persons. N Engl J Med. 2021;384(24):2273-2282. doi:10.1056/NEJMoa2104983 - DOI - PMC - PubMed
1. Kadali RAK, Janagama R, Peruru SR, et al. . Adverse effects of COVID-19 messenger RNA vaccines among pregnant women: a cross-sectional study on healthcare workers with detailed self-reported symptoms. Am J Obstet Gynecol. Published online Juen 9, 2021. doi:10.1016/j.ajog.2021.06.007 - DOI - PMC - PubMed
1. Rouse CE, Eckert LO, Babarinsa I, et al. ; Global Alignment of Immunization Safety in Pregnancy (GAIA) Abortion Work Group; Brighton Collaboration Abortion Working Group . Spontaneous abortion and ectopic pregnancy: case definition & guidelines for data collection, analysis, and presentation of maternal immunization safety data. Vaccine. 2017;35(48 pt A):6563-6574. doi:10.1016/j.vaccine.2017.01.047 - DOI - PMC - PubMed
1. Baggs J, Gee J, Lewis E, et al. . The Vaccine Safety Datalink: a model for monitoring immunization safety. Pediatrics. 2011;127(suppl 1):S45-S53. doi:10.1542/peds.2010-1722H - DOI - PubMed

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[1] Ko JY, DeSisto CL, Simeone RM, et al. . Adverse pregnancy outcomes, maternal complications, and severe illness among US delivery hospitalizations with and without a coronavirus disease 2019 (COVID-19) diagnosis. Clin Infect Dis. 2021;73(suppl 1):S24-S31. doi:10.1093/cid/ciab344 - DOI - PMC - PubMed

[2] Ko JY, DeSisto CL, Simeone RM, et al. . Adverse pregnancy outcomes, maternal complications, and severe illness among US delivery hospitalizations with and without a coronavirus disease 2019 (COVID-19) diagnosis. Clin Infect Dis. 2021;73(suppl 1):S24-S31. doi:10.1093/cid/ciab344 - DOI - PMC - PubMed

[3] Shimabukuro TT, Kim SY, Myers TR, et al. ; CDC v-safe COVID-19 Pregnancy Registry Team . Preliminary findings of mRNA COVID-19 vaccine safety in pregnant persons. N Engl J Med. 2021;384(24):2273-2282. doi:10.1056/NEJMoa2104983 - DOI - PMC - PubMed

[4] Shimabukuro TT, Kim SY, Myers TR, et al. ; CDC v-safe COVID-19 Pregnancy Registry Team . Preliminary findings of mRNA COVID-19 vaccine safety in pregnant persons. N Engl J Med. 2021;384(24):2273-2282. doi:10.1056/NEJMoa2104983 - DOI - PMC - PubMed

[5] Kadali RAK, Janagama R, Peruru SR, et al. . Adverse effects of COVID-19 messenger RNA vaccines among pregnant women: a cross-sectional study on healthcare workers with detailed self-reported symptoms. Am J Obstet Gynecol. Published online Juen 9, 2021. doi:10.1016/j.ajog.2021.06.007 - DOI - PMC - PubMed

[6] Kadali RAK, Janagama R, Peruru SR, et al. . Adverse effects of COVID-19 messenger RNA vaccines among pregnant women: a cross-sectional study on healthcare workers with detailed self-reported symptoms. Am J Obstet Gynecol. Published online Juen 9, 2021. doi:10.1016/j.ajog.2021.06.007 - DOI - PMC - PubMed

[7] Rouse CE, Eckert LO, Babarinsa I, et al. ; Global Alignment of Immunization Safety in Pregnancy (GAIA) Abortion Work Group; Brighton Collaboration Abortion Working Group . Spontaneous abortion and ectopic pregnancy: case definition & guidelines for data collection, analysis, and presentation of maternal immunization safety data. Vaccine. 2017;35(48 pt A):6563-6574. doi:10.1016/j.vaccine.2017.01.047 - DOI - PMC - PubMed

[8] Rouse CE, Eckert LO, Babarinsa I, et al. ; Global Alignment of Immunization Safety in Pregnancy (GAIA) Abortion Work Group; Brighton Collaboration Abortion Working Group . Spontaneous abortion and ectopic pregnancy: case definition & guidelines for data collection, analysis, and presentation of maternal immunization safety data. Vaccine. 2017;35(48 pt A):6563-6574. doi:10.1016/j.vaccine.2017.01.047 - DOI - PMC - PubMed

[9] Baggs J, Gee J, Lewis E, et al. . The Vaccine Safety Datalink: a model for monitoring immunization safety. Pediatrics. 2011;127(suppl 1):S45-S53. doi:10.1542/peds.2010-1722H - DOI - PubMed

[10] Baggs J, Gee J, Lewis E, et al. . The Vaccine Safety Datalink: a model for monitoring immunization safety. Pediatrics. 2011;127(suppl 1):S45-S53. doi:10.1542/peds.2010-1722H - DOI - PubMed

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Spontaneous Abortion Following COVID-19 Vaccination During Pregnancy

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Spontaneous Abortion Following COVID-19 Vaccination During Pregnancy

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