Soluble (Pro)Renin Receptor as a Negative Regulator of NCC (Na+-Cl- Cotransporter) Activity

Hypertension. 2021 Sep;78(4):1027-1038. doi: 10.1161/HYPERTENSIONAHA.121.16981. Epub 2021 Sep 8.

Abstract

[Figure: see text].

Keywords: Na+-K+ cotransporter; angiotensin II receptor type 1; arterial pressure; hyperkalemia; soluble (pro)renin receptor.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Hyperkalemia / etiology
  • Kidney Tubules, Distal / metabolism
  • Mice
  • Phosphorylation
  • Prorenin Receptor
  • Protein Serine-Threonine Kinases / physiology
  • Pyrrolidines / pharmacology
  • Receptors, Cell Surface / physiology*
  • Solute Carrier Family 12, Member 3 / physiology*

Substances

  • PF-429242
  • Pyrrolidines
  • Receptors, Cell Surface
  • Solute Carrier Family 12, Member 3
  • Prkwnk4 protein, mouse
  • Stk39 protein, mouse
  • OXSR1 protein, mouse
  • Protein Serine-Threonine Kinases
  • Prorenin Receptor