The biology of hematopoietic stem cells and its clinical implications

FEBS J. 2022 Dec;289(24):7740-7759. doi: 10.1111/febs.16192. Epub 2021 Sep 29.


Hematopoietic stem cells (HSCs) give rise to all types of blood cells and self-renew their own population. The regeneration potential of HSCs has already been successfully translated into clinical applications. However, recent studies on the biology of HSCs may further extend their clinical use in future. The roles of HSCs in native hematopoiesis and in transplantation settings may differ. Furthermore, the heterogenic pool of HSCs dynamically changes during aging. These changes also involve the complex interactions of HSCs with the bone marrow niche. Here, we review the opportunities and challenges of these findings to improve the clinical use of HSCs. We describe new methods of HSCs mobilization and conditioning for the transplantation of HSCs. Finally, we highlight the research findings that may lead to overcoming the current limitations of HSC transplantation and broaden the patient group that can benefit from the clinical potential of HSCs.

Keywords: bone marrow niche; conditioning; hematopoietic stem cells; stem cell therapy; transplantation.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biology
  • Bone Marrow
  • Hematopoiesis
  • Hematopoietic Stem Cells* / metabolism
  • Humans
  • Stem Cell Niche*