A roadmap for the Human Developmental Cell Atlas

Nature. 2021 Sep;597(7875):196-205. doi: 10.1038/s41586-021-03620-1. Epub 2021 Sep 8.


The Human Developmental Cell Atlas (HDCA) initiative, which is part of the Human Cell Atlas, aims to create a comprehensive reference map of cells during development. This will be critical to understanding normal organogenesis, the effect of mutations, environmental factors and infectious agents on human development, congenital and childhood disorders, and the cellular basis of ageing, cancer and regenerative medicine. Here we outline the HDCA initiative and the challenges of mapping and modelling human development using state-of-the-art technologies to create a reference atlas across gestation. Similar to the Human Genome Project, the HDCA will integrate the output from a growing community of scientists who are mapping human development into a unified atlas. We describe the early milestones that have been achieved and the use of human stem-cell-derived cultures, organoids and animal models to inform the HDCA, especially for prenatal tissues that are hard to acquire. Finally, we provide a roadmap towards a complete atlas of human development.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Animals
  • Atlases as Topic
  • Cell Culture Techniques
  • Cell Movement*
  • Cell Survival
  • Cell Tracking*
  • Cells / cytology*
  • Data Visualization
  • Developmental Biology / methods*
  • Embryo, Mammalian / cytology*
  • Female
  • Fetus / cytology*
  • Humans
  • Imaging, Three-Dimensional
  • Information Dissemination*
  • Male
  • Models, Animal
  • Organogenesis* / genetics
  • Organoids / cytology
  • Stem Cells / cytology