Antiprotozoal activity of diospyrin towards Leishmania donovani promastigotes in vitro

Trans R Soc Trop Med Hyg. 1987;81(5):738-41. doi: 10.1016/0035-9203(87)90013-7.

Abstract

Diospyrin, a bis-naphthoquinone derivative, isolated from a plant, known for its antitumour properties against Ehrlich ascites carcinoma in Swiss A mice, exhibits antiprotozoal activity towards L. donovani promastigotes in culture.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Dose-Response Relationship, Drug
  • Leishmania donovani / drug effects*
  • Leishmania donovani / growth & development
  • Leishmania donovani / metabolism
  • Naphthoquinones / pharmacology*
  • Oxygen Consumption
  • Time Factors

Substances

  • Naphthoquinones
  • diospyrin