Management experience of pediatric meningioma in a Mexican reference center

Ann Diagn Pathol. 2021 Dec:55:151811. doi: 10.1016/j.anndiagpath.2021.151811. Epub 2021 Sep 1.


Objective: Determine the histopathological and clinical characteristics of patients diagnosed with meningiomas and to establish the frequency of these tumors in the pediatric population Mexican. Determine the NF1/2 frequency in meningioma pediatric.

Methods: Samples from the histopathology file were reviewed, and from the complete clinical file the following patient data was reviewed: age, gender, diagnosis, diagnosis year, surgical resection, location, tumor size, symptoms, and family background. The frequency of NF1/2 in pediatric meningioma was reviewed in literature.

Results: Forty-four de novo cases were collected from pediatric patients; 19 were female patients and 25 males. The most frequent histological subtype was transitional meningioma. Of all the cases, 75% had a supratentorial localization and 20% had an extramedullary intrarachidian localization. Some clinical manifestations included seizures, paresis, headache, and visual disturbances.

Conclusion: There is a low incidence of meningiomas in the pediatric population, more than 70% are Grade I, and they have supratentorial localization.

Keywords: Histopathological diagnosis; Meningiomas; NF1/NF1 systematic review; Pediatric patients.

Publication types

  • Systematic Review

MeSH terms

  • Adolescent
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Male
  • Meningeal Neoplasms / diagnosis
  • Meningeal Neoplasms / epidemiology
  • Meningeal Neoplasms / pathology
  • Meningioma* / diagnosis
  • Meningioma* / epidemiology
  • Meningioma* / pathology
  • Mexico / epidemiology
  • Neoplasm Grading
  • Prevalence
  • Retrospective Studies
  • Young Adult