Low-Frequency Ultrasound Coupled with High-Pressure Technologies: Impact of Hybridized Techniques on the Recovery of Phytochemical Compounds

Molecules. 2021 Aug 24;26(17):5117. doi: 10.3390/molecules26175117.


The coupling of innovative technologies has emerged as a smart alternative for the process intensification of bioactive compound extraction from plant matrices. In this regard, the development of hybridized techniques based on the low-frequency and high-power ultrasound and high-pressure technologies, such as supercritical fluid extraction, pressurized liquids extraction, and gas-expanded liquids extraction, can enhance the recovery yields of phytochemicals due to their different action mechanisms. Therefore, this paper reviewed and discussed the current scenario in this field where ultrasound-related technologies are coupled with high-pressure techniques. The main findings, gaps, challenges, advances in knowledge, innovations, and future perspectives were highlighted.

Keywords: acoustic cavitation; gas-expanded liquids; pressurized liquids; supercritical CO2.

Publication types

  • Review

MeSH terms

  • Animals
  • Phytochemicals / chemistry*
  • Plants / chemistry
  • Technology / methods*
  • Ultrasonic Waves


  • Phytochemicals