Treatment of Cancer with Radio-Immunotherapy: What We Currently Know and What the Future May Hold

Int J Mol Sci. 2021 Sep 3;22(17):9573. doi: 10.3390/ijms22179573.


Radiotherapy and immunotherapy are most effective as cancer therapies in the setting of low-volume disease. Although initial studies of radio-immunotherapy in patients with metastatic cancer have not confirmed the efficacy of this approach, the role of radio-immunotherapy in patients with limited metastatic burden is unclear. We propose that further investigation of radio-immunotherapy in metastatic patients should focus upon patients with oligometastatic disease.

Keywords: immunotherapy; metastasis; oligometastasis; radio-immunotherapy; radiotherapy.

Publication types

  • Review

MeSH terms

  • Humans
  • Neoplasm Metastasis
  • Neoplasms / immunology
  • Neoplasms / pathology
  • Neoplasms / radiotherapy*
  • Radioimmunotherapy*