Salivary Gland Cancers

Hematol Oncol Clin North Am. 2021 Oct;35(5):973-990. doi: 10.1016/j.hoc.2021.05.011.


Salivary gland carcinomas are a rare and heterogenous group of cancers with varying underlying biology and clinical behavior. A quickly evolving body of data has advanced the understanding of these tumors, leading to effective therapeutics for several histologic subtypes. Biologically rational clinical trials have developed from an understanding of MYB and NOTCH signaling in adenoid cystic carcinoma. The recognition of androgen receptor signaling and HER2-targeted therapy has offered therapeutic options in non-ACC salivary cancers. The use of TRK inhibitors in salivary secretory carcinoma has led to exceptional responses. Immunotherapy is an exciting new therapeutic avenue that requires further exploration.

Trial registration: NCT03172624 NCT03146650 NCT04209660.

Keywords: Acinic cell carcinoma; Adenoid cystic carcinoma; Mucoepidermoid carcinoma; Salivary duct carcinoma; Salivary gland carcinoma.

Publication types

  • Review

MeSH terms

  • Biomarkers, Tumor
  • Breast Neoplasms*
  • Carcinoma*
  • Carcinoma, Adenoid Cystic* / therapy
  • Female
  • Humans
  • Salivary Gland Neoplasms* / therapy


  • Biomarkers, Tumor

Associated data