100 years of Mycobacterium bovis bacille Calmette-Guérin

Lancet Infect Dis. 2022 Jan;22(1):e2-e12. doi: 10.1016/S1473-3099(21)00403-5. Epub 2021 Sep 7.


Mycobacterium bovis bacille Calmette-Guérin (BCG), an experimental vaccine designed to protect cattle from bovine tuberculosis, was administered for the first time to a newborn baby in Paris in 1921. Over the past century, BCG has saved tens of millions of lives and has been given to more humans than any other vaccine. It remains the sole tuberculosis vaccine licensed for use in humans. BCG provides long-lasting strong protection against miliary and meningeal tuberculosis in children, but it is less effective for the prevention of pulmonary tuberculosis, especially in adults. Evidence mainly from the past two decades suggests that BCG has non-specific benefits against non-tuberculous infections in newborn babies and in older adults, and offers immunotherapeutic benefit in certain malignancies such as non-muscle invasive bladder cancer. However, as a live attenuated vaccine, BCG can cause localised or disseminated infections in immunocompromised hosts, which can also occur following intravesical installation of BCG for the treatment of bladder cancer. The legacy of BCG includes fundamental discoveries about tuberculosis-specific and non-specific immunity and the demonstration that tuberculosis is a vaccine-preventable disease, providing a foundation for new vaccines to hasten tuberculosis elimination.

Publication types

  • Historical Article
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • BCG Vaccine / adverse effects
  • BCG Vaccine / history*
  • BCG Vaccine / immunology*
  • Cattle
  • History, 19th Century
  • History, 20th Century
  • History, 21st Century
  • Humans
  • Mycobacterium bovis / immunology*
  • Mycobacterium bovis / pathogenicity
  • Tuberculosis, Bovine / epidemiology*
  • Tuberculosis, Bovine / immunology*
  • Tuberculosis, Bovine / microbiology
  • Tuberculosis, Bovine / prevention & control
  • Vaccines, Attenuated / immunology


  • BCG Vaccine
  • Vaccines, Attenuated