Elevated mycobacterium avium subsp. paratuberculosis (MAP) antibody titer in Japanese multiple sclerosis

J Neuroimmunol. 2021 Nov 15;360:577701. doi: 10.1016/j.jneuroim.2021.577701. Epub 2021 Aug 25.

Abstract

To investigate whether antibody production against mycobacterium avium subsp. paratuberculosis (MAP) is related to clinical characteristics of multiple sclerosis (MS) and human leukocyte antigen (HLA) alleles, IgG antibody against three MAP peptides and two human peptides homologous to MAP were measured in sera from 103 MS patients and 50 healthy controls (HCs). MS patients had higher IgG levels against MAP2694295-303 (MAP2694-IgG) than HCs, while the other antibodies were comparable. Multivariate analysis demonstrated that higher MAP2694-IgG titers were associated with higher EDSS scores, but not with HLA alleles or dairy product consumption. Immune response against MAP may worsen MS disability.

Keywords: Expanded disability status scale; Multiple sclerosis; Mycobacterium avium subsp. paratuberculosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Antibodies, Bacterial / blood*
  • Antibody Specificity
  • Antigens, Bacterial / immunology
  • Bacterial Proteins / chemistry
  • Bacterial Proteins / immunology
  • Dairy Products
  • Diet
  • Female
  • Genes, MHC Class II
  • HLA-DRB1 Chains / genetics
  • Humans
  • Immunodominant Epitopes / immunology
  • Immunoglobulin G / blood*
  • Immunoglobulin G / immunology
  • Interferon Regulatory Factors / immunology
  • Japan / epidemiology
  • Male
  • Membrane Proteins / chemistry
  • Membrane Proteins / immunology
  • Middle Aged
  • Molecular Mimicry
  • Multiple Sclerosis / cerebrospinal fluid
  • Multiple Sclerosis / epidemiology
  • Multiple Sclerosis / genetics
  • Multiple Sclerosis / immunology*
  • Mycobacterium avium subsp. paratuberculosis / immunology*
  • Myelin Basic Protein / immunology
  • Oligoclonal Bands / cerebrospinal fluid
  • Peptide Fragments / immunology
  • Receptors, Antigen, T-Cell, alpha-beta / immunology
  • Sequence Alignment
  • Sequence Homology, Amino Acid
  • Severity of Illness Index

Substances

  • Antibodies, Bacterial
  • Antigens, Bacterial
  • Bacterial Proteins
  • HLA-DRB1 Chains
  • IRF5 protein, human
  • Immunodominant Epitopes
  • Immunoglobulin G
  • Interferon Regulatory Factors
  • Membrane Proteins
  • Myelin Basic Protein
  • Oligoclonal Bands
  • Peptide Fragments
  • Receptors, Antigen, T-Cell, alpha-beta