Treatment of Eosinophilic Esophagitis: Diet or Medication?

J Allergy Clin Immunol Pract. 2021 Sep;9(9):3249-3256. doi: 10.1016/j.jaip.2021.07.029.

Abstract

Eosinophilic esophagitis (EoE) is an antigen-triggered chronic disease of increasing prevalence in children and adults. Untreated or therapy-resistant EoE leads to complications of esophageal food impactions and luminal narrowing. The past decade has seen a number of new clinical trials for EoE therapies including elimination diets, proton pump inhibitors, swallowed topical corticosteroids, and biologics. In this review, we comment on the current state of the art for dietary and pharmacologic management of EoE and the need for future clinical trials to help tailor therapies to individual patients with this chronic disease.

Keywords: Biologic; Corticosteroid; Diet; Eosinophil; Esophagus; Fibrosis; Food antigen; Proton pump inhibitor; Remodeling.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adult
  • Biological Products*
  • Child
  • Diet
  • Eosinophilic Esophagitis* / drug therapy
  • Glucocorticoids
  • Humans
  • Proton Pump Inhibitors / therapeutic use

Substances

  • Biological Products
  • Glucocorticoids
  • Proton Pump Inhibitors