Squamous cell carcinoma of the ear treated by photochemical internalization

Photodiagnosis Photodyn Ther. 2021 Dec;36:102528. doi: 10.1016/j.pdpdt.2021.102528. Epub 2021 Sep 10.


A 77-year-old Caucasian male was diagnosed with squamous cell cancer of the right ear. The patient elected to take part in the first-in-man phase I TPCS2a based bleomycin photochemical internalization (PCI). On Day 0, The patient received the photosensitiser [Amphinex (TPCS2a)], by slow intravenous injection. Four days later, surface illumination based (PCI) was implemented 3 h after the slow infusion of Bleomycin. Four weeks following the infusion of the photosensitiser, the cancerous area turned into black rigid mass with clear demarcation from the macroscopically normal skin. The size of the treated area has been substantially reduced. Histopathologic assessment of the excised necrotic mass revealed no viable tumour and the excised margins (PCI-treated margins) were tumour-free. This case was a clear indication that PCI is a clinically relevant technique that has potential in the treatment of such cancers to avoid radical intervention.

Keywords: Amphinex; Bleomycin; PCI; PDT; SCC; Sub-lethal PDT; TPCS(2a).

MeSH terms

  • Aged
  • Bleomycin
  • Carcinoma, Squamous Cell* / drug therapy
  • Cell Line, Tumor
  • Humans
  • Male
  • Photochemotherapy* / methods
  • Photosensitizing Agents / therapeutic use


  • Photosensitizing Agents
  • Bleomycin