The aim of the study was to validate the Armenian language version of the COMQ-12 quality of life (QL) instrument among teenagers with chronic otitis media (COM). A case-control study was conducted in 350 teenagers aged 16 to 18 years: the case group of patients with COM (120) and the control group of practically healthy teenagers (230). Study participants' quality of life was assessed by specific COMQ-12 (Chronic Otitis Media Questionnaire-12) and not specific SF-36 (The Short Form-36) questionnaires. Hospital Anxiety and Depression Scale (HADS) instrument has been used to assess the effect of COM on the emotional field of the patients. The expressiveness of cognitive function was assessed by the Montreal Cognitive Assessment test (MoCA). According to the research data among risk factors which had statistically significant influence on COM morbidity rate in teenagers were: presence of disabled person in a family (OR=8,8), unfavorable psychological atmosphere in the family (OR=2,9), presence of accompanying chronic disease in teenagers (OR=2,1) and presence of chronic ENT diseases in parents (OR=2,1). Use of the non-specific questionnaire showed that COM mostly influences on psychological component of Mental Healthdomain of QL, as well as Social Functioning. The average score of QL in the group with COM was 28,3, and in the practically healthy group it was 3,4 (Mann-Whitney U=1725,0; р <0,01). COM mostly influences on the following scales of the COMQ-12 questionnaire: Q-3, Q-4, Q-6, Q-8, Q-9 Q-12.There was a statistically significant correlation between the parameters of COMQ-12 and SF 36 questionnaires for the following questions: Q-4, Q-6, Q-8, Q-9, Q-12. Anxiety and depression symptoms were recorded in 52,2% of teenagers in the group of cases and in 13,4% in the control one (p<0.001). The correlation analysis has shown that among the patients with COM there is an association between anxious-depressive disorders and cognitive dysfunction. COMQ-12 questionnaire used for the first time in Armenia population among the teenagers with COM showed high reliability, internal consistency and construct validity.