Pharmacotherapeutic options for weight regain after bariatric surgery

Curr Treat Options Gastroenterol. 2021 Sep;19(3):524-541. doi: 10.1007/s11938-021-00358-7. Epub 2021 Jul 16.


Purpose of review: We sought to critically evaluate the recent literature published over the past 3 years on the topic of weight regain after bariatric surgery in children, adolescents, and adults, with an emphasis on clinically- relevant information for pharmacologic treatment of weight regain after metabolic and bariatric surgery.

Findings: There are multiple pharmacotherapeutic agents available to treat obesity in children, adolescents, and adults; these agents have varying efficacy and indications for use and have been studied in a variety of clinical and research scenarios. We present an overview of these findings.

Summary: This review represents a comprehensive compilation of the recently published data on efficacy of anti-obesity pharmacotherapy in the treatment of weight regain after bariatric surgery for children, adolescents, and adults.

Keywords: adolescence; anti-obesity pharmacotherapy; bariatric surgery; obesity; pediatric; weight regain.