Regulatory roles of tRNA-derived RNA fragments in human pathophysiology

Kush Kumar Pandey; Deeksha Madhry; Y S Ravi Kumar; Shivani Malvankar; Leena Sapra; Rupesh K Srivastava; Sankar Bhattacharyya; Bhupendra Verma

doi:10.1016/j.omtn.2021.06.023

Regulatory roles of tRNA-derived RNA fragments in human pathophysiology

Mol Ther Nucleic Acids. 2021 Jul 2:26:161-173. doi: 10.1016/j.omtn.2021.06.023. eCollection 2021 Dec 3.

Authors

Kush Kumar Pandey¹, Deeksha Madhry¹, Y S Ravi Kumar², Shivani Malvankar¹, Leena Sapra¹, Rupesh K Srivastava¹, Sankar Bhattacharyya³, Bhupendra Verma¹

Affiliations

¹ Department of Biotechnology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India.
² Department of Biotechnology, M.S. Ramaiah, Institute of Technology, MSR Nagar, Bengaluru, India.
³ Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, India.

Abstract

Hundreds of tRNA genes and pseudogenes are encoded by the human genome. tRNAs are the second most abundant type of RNA in the cell. Advancement in deep-sequencing technologies have revealed the presence of abundant expression of functional tRNA-derived RNA fragments (tRFs). They are either generated from precursor (pre-)tRNA or mature tRNA. They have been found to play crucial regulatory roles during different pathological conditions. Herein, we briefly summarize the discovery and recent advances in deciphering the regulatory role played by tRFs in the pathophysiology of different human diseases.

Keywords: RNases; human diseases; lncRNA; pathophysiology; sncRNA; stress; tRFs; tRNA processing; tiRNA; tsRNA.

Publication types

Review