Fe3O4@SiO2@CeO2 as a Potential Nanomagnetic Carrier for Oral Delivery System and Release of Celecoxib

Abstract

Aims and objective: In this study, an attempt was made to synthesize, characterize, and develop many applications of functionalized rare metal oxide nanoparticles. Herein, a new strategy for drug delivery is developed to functionalize magnetite nanoparticles to improve their performances in the delivery of celecoxib.

Materials and methods: Magnetite Fe₃O₄@SiO₂ nanoparticles are synthesized by the sol-gel method. The surface of the hydroxyl groups was extended by treating with cerium nitrate salt; finally, sodium hydroxide was anchored to the surface hydroxyl groups to produce cerium oxidefunctionalized Fe₃O₄@SiO₂@CeO₂ magnetic nanoparticles (FSC). The synthesized sample was characterized by FT-IR, FESEM, VSM, TGA, and XRD. Afterward, the functionalized nanoparticles were examined in the delivery of celecoxib as an active drug model involving cerium oxide and hydroxyl functional groups.

Results: For this purpose, the amount of loading/release of the drug was investigated in different amounts of nanocomposite and pH values.

Conclusion: The results of the present investigation indicate that the formulations (m_FSC=5 mg, pH=3.3) can be considered as best among various formulations with respect to particle size, entrapment efficiency, and in-vitro successful drug release.

Keywords: Celecoxib; SEM; XRD; drug delivery; magnetite; nanocomposite.