Long non-coding RNA SNHG16 as a potential biomarker in hepatocellular carcinoma: A meta-analysis

Medicine (Baltimore). 2021 Sep 10;100(36):e27178. doi: 10.1097/MD.0000000000027178.


Small nucleolar RNA host gene 16 (SNHG16) has recently been reported as a potential biomarker in various cancers. However, the prognostic value of SNHG16 in hepatocellular carcinoma (HCC) has not been investigated yet. Therefore, the purpose of this study was to reveal the association between SNHG16 expression and clinicopathological characteristics of HCC.Standards-compliant literature was retrieved from multiple public databases, and data on overall survival, disease-free survival, and clinicopathological characteristics related to SNGH16 were extracted and meta-analysis was performed. Additionally, the Cancer Genome Atlas data were analyzed through the gene expression profiling interactive analysis database to verify previous results.A total of 5 reports involving 410 patients with HCC were enrolled. The high expression of SNHG16 indicated worse overall survival (hazard ratio, 2.10; 95% CI, 1.22-3.60; P = .007) and disease-free survival (hazard ratio, 3.38; 95% CI, 1.10-10.40; P = .03). Additionally, the high expression of SNHG16 predicted a larger tumor size, metastasis, and advanced TNM stage.SNHG16 could serve as a potential biomarker of poor prognosis in HCC.

Publication types

  • Meta-Analysis

MeSH terms

  • Biomarkers, Tumor / genetics
  • Carcinoma, Hepatocellular / metabolism*
  • Carcinoma, Hepatocellular / pathology
  • Humans
  • Liver Neoplasms / metabolism*
  • Liver Neoplasms / pathology
  • Prognosis
  • RNA, Long Noncoding / genetics*


  • Biomarkers, Tumor
  • RNA, Long Noncoding
  • SNHG16 lncRNA, human