MEF2D-NR4A1-FAM134B2-mediated reticulophagy contributes to amino acid homeostasis

Autophagy. 2022 May;18(5):1049-1061. doi: 10.1080/15548627.2021.1968228. Epub 2021 Sep 14.

Abstract

AAD: amino acid deficiency; APOC3: apolipoprotein C3; BACH1: BTB domain and CNC homolog 1; CEBP: CCAAT enhancer binding protein; DDIT3/CHOP: DNA damage inducible transcript 3; EBSS: Earle's Balanced Salt Solution; EIF2AK4/GCN2: eukaryotic translation initiation factor 2 alpha kinase 4; ER: endoplasmic reticulum; HisOH: histidinol; ISR: integrated stress response; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MEF2D: myocyte enhancer factor 2D; MTOR: mechanistic target of rapamycin kinase; NR4A1: nuclear receptor subfamily 4 group A member 1; RETREG1/FAM134B: reticulophagy regulator 1; RTN2: reticulon 2, TF: transcription factor; TFEB: transcription factor EB; ZBTB10: zinc finger and BTB domain containing 10.

Keywords: Amino acid deficiency; FAM134B2; MEF2D; NR4A1; reticulophagy.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Amino Acids / metabolism
  • Autophagy* / genetics
  • Carrier Proteins / metabolism
  • Endoplasmic Reticulum Stress
  • Endoplasmic Reticulum* / metabolism
  • Homeostasis

Substances

  • Amino Acids
  • Carrier Proteins