MEF2D-NR4A1-FAM134B2-mediated reticulophagy contributes to amino acid homeostasis

Yuji Shiozaki; Shinobu Miyazaki-Anzai; Audrey L Keenan; Makoto Miyazaki

doi:10.1080/15548627.2021.1968228

MEF2D-NR4A1-FAM134B2-mediated reticulophagy contributes to amino acid homeostasis

Autophagy. 2022 May;18(5):1049-1061. doi: 10.1080/15548627.2021.1968228. Epub 2021 Sep 14.

Authors

Yuji Shiozaki¹, Shinobu Miyazaki-Anzai¹, Audrey L Keenan¹, Makoto Miyazaki¹

Affiliation

¹ Department of Medicine, Division of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

Abstract

AAD: amino acid deficiency; APOC3: apolipoprotein C3; BACH1: BTB domain and CNC homolog 1; CEBP: CCAAT enhancer binding protein; DDIT3/CHOP: DNA damage inducible transcript 3; EBSS: Earle's Balanced Salt Solution; EIF2AK4/GCN2: eukaryotic translation initiation factor 2 alpha kinase 4; ER: endoplasmic reticulum; HisOH: histidinol; ISR: integrated stress response; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MEF2D: myocyte enhancer factor 2D; MTOR: mechanistic target of rapamycin kinase; NR4A1: nuclear receptor subfamily 4 group A member 1; RETREG1/FAM134B: reticulophagy regulator 1; RTN2: reticulon 2, TF: transcription factor; TFEB: transcription factor EB; ZBTB10: zinc finger and BTB domain containing 10.

Keywords: Amino acid deficiency; FAM134B2; MEF2D; NR4A1; reticulophagy.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Amino Acids / metabolism
Autophagy* / genetics
Carrier Proteins / metabolism
Endoplasmic Reticulum Stress
Endoplasmic Reticulum* / metabolism
Homeostasis

Substances

Amino Acids
Carrier Proteins

Abstract

Publication types

MeSH terms

Substances

Grants and funding