Small intestine leiomyosarcoma mimicking gastrointestinal stromal tumour

BMJ Case Rep. 2021 Sep 13;14(9):e244381. doi: 10.1136/bcr-2021-244381.


Small bowel malignant tumours make only 2% of all gastrointestinal (GI) malignancies. Small bowel leiomyosarcoma (LMS) is further rare, accounts for only 0.1%-3% fraction of these tumours. These cases can present as asymptomatic intra-abdominal mass, anaemia due to GI bleed or acute abdomen such as perforation peritonitis, intussusception and bowel ischaemia. Standard of care is surgical resection. Our case presented as large lobulated exophytic ileal LMS measuring 10.8×11×14.7 cm involving multiple small bowel loops and abutting right iliac vessels and uterus. Patient's clinical course was complicated with COVID-19 positivity, deep vein thrombosis and pulmonary thromboembolism. She was managed by preoperative anticoagulation followed by resection of the tumour with end ileostomy.

Keywords: gastrointestinal surgery; small intestine cancer; surgical oncology; venous thromboembolism.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • COVID-19*
  • Female
  • Gastrointestinal Stromal Tumors* / diagnosis
  • Gastrointestinal Stromal Tumors* / surgery
  • Humans
  • Intestinal Neoplasms* / diagnosis
  • Intestinal Neoplasms* / surgery
  • Intestine, Small / diagnostic imaging
  • Intestine, Small / surgery
  • Leiomyosarcoma* / diagnosis
  • Leiomyosarcoma* / surgery
  • SARS-CoV-2