Multinational Observational Cohort Study of COVID-19-Associated Pulmonary Aspergillosis1

Emerg Infect Dis. 2021 Nov;27(11):2892-2898. doi: 10.3201/eid2711.211174. Epub 2021 Sep 14.


We performed an observational study to investigate intensive care unit incidence, risk factors, and outcomes of coronavirus disease-associated pulmonary aspergillosis (CAPA). We found 10%-15% CAPA incidence among 823 patients in 2 cohorts. Several factors were independently associated with CAPA in 1 cohort and mortality rates were 43%-52%.

Keywords: Aspergillus; COVID-19; SARS; SARS-CoV-2; coronavirus; coronavirus disease; epidemiology; fungi; invasive pulmonary aspergillosis; mortality rates; mycology; respiratory infections; risk factors; severe acute respiratory syndrome coronavirus 2; viruses; zoonoses.

Publication types

  • Observational Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • COVID-19*
  • Cohort Studies
  • Humans
  • Invasive Pulmonary Aspergillosis*
  • Pulmonary Aspergillosis*
  • SARS-CoV-2