Mechanical cell competition in human pluripotent stem cell cultures

Dev Cell. 2021 Sep 13;56(17):2401-2402. doi: 10.1016/j.devcel.2021.08.011. Epub 2021 Sep 13.


Human induced pluripotent stem cells (hIPSCs) are an important tool, but challenges remain in optimizing their use. hIPSC cultures frequently become contaminated and overrun with cells containing genetic aberrations. In this issue of Developmental Cell, Price et al. establish that this results from cell competition between wild-type and variant cells.

Publication types

  • Comment

MeSH terms

  • Cell Competition
  • Cell Differentiation
  • Humans
  • Induced Pluripotent Stem Cells*
  • Pluripotent Stem Cells*