Objective: To explore the correlation between eosinophils (Eos) and the incidence of chronic sinusitis with nasal polyps (CRSwNP) in Xinjiang region of China by comparing the proportion of inflammatory cells in the pathological tissues and peripheral blood. Methods: Retrospective analysis was performed on 582 patients with CRSwNP who underwent endoscopic nasal surgery in the First Affiliated Hospital of Xinjiang Medical University from January 2012 to March 2018, including 367 males and 215 females, aged (45.5±13.4) years (x¯±s). Patients were divided into groups according to demographic characteristics, recurrence and complication of allergic rhinitis (AR). Preoperative blood routine and postoperative pathological section data of nasal polyps were collected to compare the ratio of inflammatory cells in pathological tissue and the ratio of peripheral blood Eos in each group. The correlation between the proportion of inflammatory cells in the pathological tissue of nasal polyps and the recurrence of CRSwNP was analyzed, as well as the distribution of (eosCRSwNP) in Uygur and Han CRSwNP patients in Xinjiang region. Statistical analysis was performed by SPSS 19.0 software. Results: Compared with non-recurrent CRSwNP patients, the ratio of Eos in nasal polyp tissue and peripheral blood was increased significantly, (Z value was -3.142 and -2.344, respectively, both P<0.05). Compared with CRSwNP patients without AR, the ratio of Eos in nasal polyps and peripheral blood was also increased significantly in patients with AR (Z value was -6.664 and -4.520, respectively, both P<0.05). There was a positive correlation between tissue Eos and CRSwNP recurrence (r=0.130, P=0.002). The majority of CRSwNP patients were both eosCRSwNP in Uygur and Han ethnic groups. Conclusions: Eos is associated with the recurrence of CRSwNP in Xinjiang region, and eosCRSwNP is the dominant factor in both Uygur and Han patients.
目的： 通过对比鼻息肉病理组织及外周血中炎性细胞的占比，探讨嗜酸粒细胞（Eos）与新疆地区慢性鼻窦炎伴鼻息肉（CRSwNP）发病的相关性。 方法： 回顾性分析2012年1月至2018年3月于新疆医科大学第一附属医院就诊并行鼻内镜手术的CRSwNP患者582例，其中男性367例，女性215例，年龄（45.5±13.4）岁（x¯±s）。将患者按人口学特征、是否复发、是否合并变应性鼻炎（AR）进行分组，收集术前血常规及术后鼻息肉组织病理切片资料，对比各组病理组织中炎性细胞及外周血Eos占比。分析鼻息肉病理组织中炎性细胞占比与CRSwNP复发是否有相关性，以及新疆地区维吾尔族及汉族CRSwNP患者中嗜酸粒细胞性慢性鼻窦炎伴鼻息肉（eosCRSwNP）的分布情况。使用SPSS 19.0软件对数据进行统计学分析。 结果： 复发与非复发的CRSwNP患者相比，鼻息肉组织及外周血中Eos占比显著升高，差异均有统计学意义（Z值分别为-3.142、-2.344，P值均<0.05）；合并AR与不合并AR的CRSwNP患者相比，鼻息肉组织及外周血中Eos占比亦显著升高，差异均有统计学意义（Z值分别为-6.664、-4.520，P值均<0.05）。CRSwNP中组织Eos与CRSwNP复发呈正相关（r=0.130，P=0.002）。维吾尔族及汉族CRSwNP患者均以eosCRSwNP为主。 结论： Eos与新疆地区CRSwNP复发有关，维吾尔族和汉族患者均以eosCRSwNP为主。.