Electrochemically promoted oxidative α-cyanation of tertiary and secondary amines using cheap AIBN

Qing-Wen Gui; Zhi-Yuan Xiong; Fan Teng; Tian-Cheng Cai; Qiang Li; Wenxia Hu; Xiaoli Wang; Jialing Yu; Xiaoying Liu

doi:10.1039/d1ob01416a

Electrochemically promoted oxidative α-cyanation of tertiary and secondary amines using cheap AIBN

Org Biomol Chem. 2021 Oct 6;19(38):8254-8258. doi: 10.1039/d1ob01416a.

Authors

Qing-Wen Gui^{1

2}, Zhi-Yuan Xiong¹, Fan Teng¹, Tian-Cheng Cai¹, Qiang Li^{1

3}, Wenxia Hu¹, Xiaoli Wang¹, Jialing Yu¹, Xiaoying Liu¹

Affiliations

¹ College of Chemistry and Materials Science, Hunan Agricultural University, Changsha 410128, People's Republic of China. gqw1216@hunau.edu.cn.
² State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, People's Republic of China.
³ College of Agronomy, Hunan Agricultural University, Changsha 410128, People's Republic of China.

PMID: 34523663
DOI: 10.1039/d1ob01416a

Abstract

The electrochemical α-cyanation of tertiary and secondary amines has been developed by using a cheap cyanide reagent, azobisisobutyronitrile (AIBN). The CN radical, generated through n-Bu₄NBr-meidated electrochemical oxidation, participates in a novel α-cyanation reaction under exogenous oxidant-free conditions.

Publication types

Research Support, Non-U.S. Gov't