Amyloid beta emerges from below the neck to disable the brain

PLoS Biol. 2021 Sep 15;19(9):e3001388. doi: 10.1371/journal.pbio.3001388. eCollection 2021 Sep.


Accumulation of amyloid beta (Aβ) in the brain in Alzheimer disease drives pathophysiology. A study in this issue of PLOS Biology revealed that Aβ from the liver can promote brain pathology, supporting that peripheral Aβ can contribute to neurodegeneration.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Alzheimer Disease*
  • Amyloid beta-Peptides* / metabolism
  • Brain / metabolism
  • Dendritic Spines / metabolism
  • Humans


  • Amyloid beta-Peptides