SPYing on triplet repeat expansions: Insights into FAN1-MLH1 interaction and regulation

Robert S Lahue

doi:10.1016/j.celrep.2021.109736

SPYing on triplet repeat expansions: Insights into FAN1-MLH1 interaction and regulation

Cell Rep. 2021 Sep 14;36(11):109736. doi: 10.1016/j.celrep.2021.109736.

Author

Robert S Lahue¹

Affiliation

¹ Centre for Chromosome Biology, National University of Ireland, Galway, Ireland; Galway Neuroscience Centre, National University of Ireland, Galway, Ireland. Electronic address: bob.lahue@nuigalway.ie.

PMID: 34525375
DOI: 10.1016/j.celrep.2021.109736

Abstract

The DNA repair proteins FAN1 and MLH1 have opposing effects on triplet repeat expansions. New studies by Goold et al. (2021) and Porro et al. (2021) pinpoint interactions between FAN1 and MLH1 that cross-regulate each other's activities.

Publication types

Comment

MeSH terms

Endodeoxyribonucleases* / metabolism
Exodeoxyribonucleases* / metabolism
Multifunctional Enzymes / metabolism
Trinucleotide Repeat Expansion / genetics

Substances

Multifunctional Enzymes
Endodeoxyribonucleases
Exodeoxyribonucleases