Peeling Skin Syndrome: An Easily Missed Rare Entity

Skinmed. 2021 Aug 1;19(4):305-307. eCollection 2021.


A 6-year-old boy with Down's syndrome presented with recurrent episodes of asymptomatic peeling of the skin from the trunk, palms, soles, and face since he was 2 years old. He was the first child of a non-consanguineous marriage. There was no history of any seasonal aggravation or variation. The peeling occurred once or twice a month. Several pediatricians and dermatologists diagnosed it to be either a staphylococcal scalded skin syndrome or a drug reaction. A temporal correlation could not be established with any drugs, including cefixime, amoxicillin, and paracetamol.

Publication types

  • Case Reports

MeSH terms

  • Child
  • Child, Preschool
  • Dermatitis, Exfoliative* / diagnosis
  • Humans
  • Male
  • Skin
  • Skin Diseases, Genetic*
  • Staphylococcal Scalded Skin Syndrome*

Supplementary concepts

  • Peeling Skin Syndrome