Stem cells part of the innate and adaptive immune systems as a therapeutic for Covid-19

Commun Integr Biol. 2021 Sep 10;14(1):186-198. doi: 10.1080/19420889.2021.1965356. eCollection 2021.


Some stem cell types not only release molecules that reduce viral replication, but also reduce the hypercytokinemia and inflammation induced by the immune system, and have been found to be part of the innate and adaptive immune systems. An important component of the stem cell's ability to ameliorate viral diseases, especially the complications post-clearance of the pathogen, is the ability of adult stem cells to reset the innate and adaptive immune systems from an inflammatory state to a repair state. Thus, the molecules released from certain stem cell types found to be safe and efficacious, may be an important new means for therapeutic development in Covid-19, especially for late-stage inflammation and tissue damage once the virus has cleared, particularly in the aged population.

Keywords: Adult stem cells; Covid-19; adipose derived mesenchymal stem cells; immune system; inflammation; viral infection.

Publication types

  • Review