A tumor-cell biomimetic nanoplatform embedding biological enzymes for enhanced metabolic therapy

Chem Commun (Camb). 2021 Sep 16;57(74):9398-9401. doi: 10.1039/d1cc03494d.

Abstract

A tumor cell membrane-camouflaged therapeutic system was fabricated to eliminate tumors by embedding apyrase and glucose oxidase (GOx) into zeolitic imidazolate framework-8 (ZIF-8) nanoparticles for tumor-targeted metabolic therapy. Experimental results demonstrated that these functional nanoparticles could disturb the energy supply of tumor cells by depleting ATP and glucose and efficiently induce tumor cell death.

MeSH terms

  • Adenosine Triphosphate / metabolism
  • Apyrase / metabolism*
  • Biomimetic Materials / chemistry
  • Biomimetic Materials / metabolism*
  • Cell Death / drug effects
  • Glucose / metabolism
  • Glucose Oxidase / metabolism*
  • Humans
  • Metal-Organic Frameworks / chemistry
  • Metal-Organic Frameworks / metabolism*
  • Metal-Organic Frameworks / pharmacology
  • Nanoparticles / chemistry
  • Nanoparticles / metabolism*
  • Neoplasms / drug therapy
  • Neoplasms / metabolism*
  • Neoplasms / pathology

Substances

  • Metal-Organic Frameworks
  • Adenosine Triphosphate
  • Glucose Oxidase
  • Apyrase
  • Glucose