Immune correlates of protection by mRNA-1273 vaccine against SARS-CoV-2 in nonhuman primates

Science. 2021 Sep 17;373(6561):eabj0299. doi: 10.1126/science.abj0299. Epub 2021 Sep 17.

Abstract

[Figure: see text].

Publication types

  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Antibodies, Neutralizing / blood*
  • Antibodies, Neutralizing / immunology
  • Antibodies, Viral / blood*
  • Antibodies, Viral / immunology
  • Antibody Affinity
  • Bronchoalveolar Lavage Fluid / immunology
  • Bronchoalveolar Lavage Fluid / virology
  • CD4-Positive T-Lymphocytes / immunology
  • COVID-19 / immunology
  • COVID-19 / prevention & control*
  • COVID-19 / virology
  • COVID-19 Vaccines / administration & dosage*
  • COVID-19 Vaccines / immunology*
  • Female
  • Immunization Schedule
  • Immunization, Passive
  • Immunization, Secondary
  • Immunogenicity, Vaccine*
  • Immunoglobulin G / immunology
  • Immunologic Memory
  • Lung / immunology
  • Lung / virology
  • Macaca mulatta
  • Male
  • Mesocricetus
  • Nasal Mucosa / immunology
  • Nasal Mucosa / virology
  • SARS-CoV-2 / immunology*
  • SARS-CoV-2 / physiology
  • Spike Glycoprotein, Coronavirus / immunology
  • Vaccination
  • Vaccine Potency
  • Virus Replication

Substances

  • Antibodies, Neutralizing
  • Antibodies, Viral
  • COVID-19 Vaccines
  • Immunoglobulin G
  • Spike Glycoprotein, Coronavirus
  • spike protein, SARS-CoV-2
  • mRNA-1273 vaccine