Poly (Adenosine Diphosphate Ribose) Polymerase-1 Single Nucleotide Polymorphism in the 3'-Untranslated Region for Ischemic Stroke Risk Reduction

Curr Neurovasc Res. 2021;18(3):302-306. doi: 10.2174/1567202618666210916122553.

Abstract

Objective: To determine the effect of PARP1 polymorphism on gene interactions.

Methods: A total of 500 patients and 500 healthy controls were enrolled.

Results: Analysis of clinical data showed that patients with stroke, diabetes, hypertension, and elevated serum triglyceride levels had higher levels of alcohol and smoking. The polymorphism of PARP1rs8679 was inversely associated with the risk of ischemic stroke. Patients with PARP1rs8679AG/ GG genotypes had a lower incidence of an initial stroke. Compared with the wild genotype, mRNA levels of PARP1 were reduced. MiR-124-5p directly induced PARP1 inhibition through the gain binding ability of 3 'UTR binding.

Conclusion: Single nucleotide polymorphism (SNP) rs8679 in PARP13'UTR can prevent ischemic stroke.

Keywords: Bioinformatics; PARP1; factor.; ischemic stroke; miRNA; protect.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 3' Untranslated Regions
  • Adenosine Diphosphate Ribose
  • Case-Control Studies
  • Genetic Predisposition to Disease / genetics
  • Genotype
  • Humans
  • Ischemic Stroke* / genetics
  • Poly (ADP-Ribose) Polymerase-1
  • Polymorphism, Single Nucleotide / genetics
  • Risk Reduction Behavior
  • Stroke* / etiology

Substances

  • 3' Untranslated Regions
  • Adenosine Diphosphate Ribose
  • PARP1 protein, human
  • Poly (ADP-Ribose) Polymerase-1