Animal Models for COVID-19: Hamsters, Mouse, Ferret, Mink, Tree Shrew, and Non-human Primates

Shuyu Shou; Menghui Liu; Yang Yang; Ning Kang; Yingying Song; Dan Tan; Nannan Liu; Feifei Wang; Jing Liu; Youhua Xie

doi:10.3389/fmicb.2021.626553

Animal Models for COVID-19: Hamsters, Mouse, Ferret, Mink, Tree Shrew, and Non-human Primates

Front Microbiol. 2021 Aug 31:12:626553. doi: 10.3389/fmicb.2021.626553. eCollection 2021.

Authors

Shuyu Shou¹, Menghui Liu¹, Yang Yang¹, Ning Kang¹, Yingying Song¹, Dan Tan¹, Nannan Liu¹, Feifei Wang¹, Jing Liu¹, Youhua Xie^{1

2}

Affiliations

¹ Key Laboratory of Medical Molecular Virology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
² Children's Hospital, Fudan University, Shanghai, China.

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel coronavirus causing acute respiratory tract infection in humans. The virus has the characteristics of rapid transmission, long incubation period and strong pathogenicity, and has spread all over the world. Therefore, it is of great significance to select appropriate animal models for antiviral drug development and therapeutic effect evaluation. Here, we review and compare the current animal models of SARS-CoV-2.

Keywords: ACE2 (angiotensin converting enzyme 2); COVID-19; SARS-CoV-2; animal model; pathogenesis.

Publication types

Review